ASRM / IFFS 2013 – Video Poster Presentations

Hamilton Thorne CASA and laser products were featured in many of the poster and oral presentations at the America Society of Reproductive Medicine (ASRM) 2013 annual meeting, held in Boston from October 13 through 16.

We thank Lani Burkman, Ph.D., and Rachana George, M.D. for taking the time to help us record videos of their poster presentations so we could share it with others.

Dr. Burkman’s poster, “Consistent Predictor of Pregnancy (PREG) and sperm fertilizing potential: Advanced Semen Analysis (ASA) and Hyperactivation (HA) using Clear CASA for local or remote patients,” outlines how computer assisted sperm analysis can be used to predict the fertilizing potential of the man.

Download PDF of the Burkman Poster

Dr. George’s poster, Defining the fertile man with Clear CASA: Capacitation (CAP) and  Hyperactivation (HA), helped in determining the definition of a hyperactivated sperm using the kinematics measurements determined by CASA.

Download PDF of  the George Poster

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Synchronicity: The XYClone Laser Helps Researchers Study Cardiac Injury and Repair

In a study published July 17, 2013 in the International Journal of Cardiology on line, researchers found that “laser-targeted injury of the zebrafish embryonic heart is a novel and reproducible model of cardiac injury and repair suitable for pharmacological and molecular studies.”

The scientific team, led by Dr. Martin Denvir, College of Medicine and Veterinary Medicine, University of Edinburgh, UK, undertook this study to learn more about how the embryonic zebrafish heart responds to injury as compared to the adult zebrafish heart, which demonstrates a remarkable capacity for regeneration.

At the “heart” of this study was the XYClone infrared laser with RED-i target. The researchers produced targeted and highly localized injury to the embryonic heart by synchronizing the XYClone laser pulse with the cardiac cycle. By using custom software, they were able to apply the laser pulse only at a specific user-designated phase of the cardiac cycle, which allowed targeting of just the embryonic heart ventricle.

Zebrafish embryos 72 hpf (lower panel)were used for all experiments of laser injury. The laser pulse was delivered to the area of the ventricle indicated by the red dot (Panel A) and resulted in a clear burn-mark at the point of injury (Panel B), see also supplementary movie 1 (V – ventricle, BA – bulbus arteriosus, At – atrium). Position of the embryo is marked by compass lines (c-caudal, cr-cranial, d-dorsal, v-ventral)

Zebrafish embryos 72 hpf (lower panel)were used for all experiments of laser injury. The laser pulse was delivered to the area of the ventricle indicated by the red dot (Panel A) and resulted in a clear burn-mark at the point of injury (Panel B), see also supplementary movie 1 (V – ventricle, BA – bulbus arteriosus, At – atrium). Position of the embryo is marked by compass lines (c-caudal, cr-cranial, d-dorsal, v-ventral)

Cardiac arrest and cessation of tail blood flow demonstrated the immediate injurious effects of the laser. In addition, cell death and apoptosis resulted in loss of cardiomyocytes. A significant decrease in heart function was observed, yet, by 24 hours post-lasering, complete recovery occurred. The study results showed, for the first time, that a proliferation of new cardiomyocytes drove the functional recovery of the lasered embryo heart ventricle. It also appeared that the laser injury itself stimulated the proliferative process.

In the discussion, the authors note many advantages to using the laser model, including the rate at which the individual zebrafish embryos may be processed, the reproducibility, the ease of testing pharmacological and genetic interventions, and the ability to create regional damage similar to that which occurs from ligation of the coronary artery in mammals.


MOVIE 1: Laser pulse injury (without synchronisation) of the zebrafish embryonic heart ventricle at 72 h post-fertilization– A single laser pulse, using the XYClone Laser Ablator, to the ventricle of a zebrafish embryo (72 hpf) results in instantaneous cardiac injury associated with marked bradycardia and gradual recovery of cardiac rhythm over the next few minutes. A laser burn-mark is clearly seen in the wall of the ventricle. This is an example where there is a clear view of non-overlapped cardiac chambers.


MOVIE 2: Laser pulse injury using the synchronization software of the zebrafish embryonic heart ventricle at 72 h post-fertilization. In this example, atrium and ventricle are overlapped. Attempting to injure the ventricle with a non-synchronized laser system would result in damage to adjacent structures. Synchronizing the laser pulse with the cardiac cycle allows highly precise and targeted injury to the ventricle at end-diastole and consequently minimizes damage to surrounding structures.

READ THE FULL ARTICLE

OA Open Access Article

Reference: Matrone G, Taylor JM, Wilson KS, Baily J, Love GD, Girkin JM, Mullins JJ, Tucker CS, Denvir MA. Laser-targeted ablation of the zebrafish embryonic ventricle: A novel model of cardiac injury and repair. Int J Cardiol. 2013 Jul 17. doi:pii: S0167-5273(13)01117-0. 10.1016/j.ijcard.2013.06.063. [Epub ahead of print] PubMed PMID: 23871347

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Supreme Court Settles Question in Stem Cell Funding

For the past three years, a cloud has hung over the question of US government funding for stem cell research.  Earlier this week, the Supreme Court settled the issue when it denied certiorari in the case of Shirley v. Sebelius, thereby letting stand the appeals court decision striking down a lawsuit that challenged the government’s ability to fund embryonic stem cell research.

The various twists and turns of this case are best handled by legal scholars1, but for those of us supportive of stem cell research, this is welcome news.

With an administration supportive of funding stem cell research in office for four at least more years, researchers will now be able to move forward with all varieties of stem cell research, without the threat that funding from the National Institutes of Health (NIH) would be ended.

Though I can’t resist the irony that this case was brought by proponents of adult stem cell research, arguing that they would be harmed if embryonic stem cell researchers received funding.  So much for free scientific inquiry
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Hamilton Thorne Ranked As Top 20 Medical Device Company By The Boston Business Journal

The October 12th, 2012 issue of the Boston Business Journal ranked Hamilton Thorne in their top 20 list of “Area’s Largest Medical Device Companies.”

Hamilton Thorne is honored to have made the 2012 list and proud of the accomplishments that our employees have achieved to make the Company a success. We are also especially proud that our lasers and imaging products have enabled some of the most ground-breaking research at our customer sites in the fields of fertility, stem cell research and development biology.

 

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Did you know that Hamilton Thorne has a YouTube Channel?

Hamilton Thorne is dedicated to helping researchers and clinicians learn the latest and most effective lab techniques, featuring videos and images from some of the world’s leading labs.

Subscribe today to see videos on embryo biopsy, laser-assisted IVF, IMSI-Strict and so much more: http://www.youtube.com/user/HamiltonThorne

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How to Manage A Successful Webinar: 3 Key Elements

If your Company is evaluating the sales potential of a Webinar to promote your products or services, you must consider the following three foundational elements in order to be successful.

  1.  Compelling Content: Yes, your products are bleeding-edge and have a great reputation in their respective markets, but Webinar attendees did not want to sit through an infomercial. Before starting the process, carefully consider what content would serve your Company (and sales needs) best.  If your key audience members are generally researchers, then give them useful discussion topics with a hands-on theme. Be sure to pick general hot-button research applications, lessons learned, tricks of the trade, and how-to guides. Once you have the top-level topic in place, then you can highlight how your products and tools can facilitate and overcome these common pain points. It also helps to add dynamic photos and videos, but be sure that this multi-media content works before you conduct the Webinar.
  2.  Guest Speakers: A well-known Company representative can certainly be a draw, but your guest speaker is honestly who they come to hear. A thought leader’s opinion regarding your products will not only carry more weight, but can also help demonstrate to Webinar attendees that they too can overcome the same hurdles and get positive results; usually more quickly and efficiently than the methods or tools they are currently using. Make sure that your guest speaker is carefully walked through the process, and offer as many rehearsals as needed. The more comfortable the guest speaker is with their process and presentation, the more engaging the Webinar becomes.
  3. Time, Resources and Commitment: This is the most important factor of the three. You can have the most engaging content, a renowned industry leader as your guest speaker, and an excellent pre-registration response rate, but if your Webinar is not properly broadcasted or there are severe technical problems, then attendees will promptly leave the Webinar and you won’t be able to leverage the recording for  future downloads. When it comes to Webinars, the devil is in the details. If your PR or Marketing departments cannot devote the time to thoroughly manage the process, then seriously consider not moving forward or hire an outside firm . Technology problems will always occur, but most can be avoided or worked around with a few rehearsals and frequent testing of the equipment. All speakers need to have their content ready ahead of time for practice and timing, and this preparation also includes moderator scripts, attendee polls, post-Webinar surveys, etc.

If your Company can successfully manage these 3  elements, then a Webinar is definitely worth the effort. Webinars are a cost-effective tool that can produce significant ROI if you strike the right balance between engaging content and product discussion.  Interested in learning more about what goes into the process? You can access the Hamilton Thorne Webinar Series here, and be sure to listen to our latest, and most popular, Webinar on “Advantages of Using Lasers in Embryo Biopsy Procedures” with guest speaker, Dr. Barry Behr of Stanford University.

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BIO Conference Comes to Boston But Still Has International Focus

I had recently attended the BIO International Conference, and although it was held in Hamilton Thorne’s backyard of Boston, it was great to see that the event is still very globally focused.

In this interview of Jeremy Abbate of Scientific American, he discusses how individual countries are still striving for expansion and innovation, despite a shrinking economy. R & D spending remains a vital component for the biosciences community, and some Governments are doing a better job than others with supporting scientific research. It’s an interesting interview and worth a listen: http://vimeo.com/44381556

 

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New Webinar on June 26 “Advantages of Using Lasers in Embryo Biopsy Procedures”

 

 

 

 

 

 

 

 

Hamilton Thorne is holding a FREE webinar entitled, “Advantages of Using Lasers in Embryo Biopsy Procedures.” Please register here if you would like to attend: https://www4.gotomeeting.com/register/428180015

Date and Time: June 26, 2012, 11:00 a.m. EDT/8:00 a.m. PDT

  • Guest Speaker:  Barry Behr, Ph.D, HCLD, Professor, Stanford University Medical Center
  • Hamilton Thorne Panelist: Diarmaid H. Douglas-Hamilton, Chief Technology Officer, Senior Vice President of Research & Development and Co-founder.

Webinar Summary:

Learn how infra-red lasers are used in clinical embryology including laser effects, hatching and trophectoderm biopsy. Attendees will also learn about the recent advances made in pre-implantation Genetic Diagnosis (PGD), as well as best practices for current methods of biopsy, including biopsy media considerations, hatching techniques, and what number of INTACT cells to be removed. The speakers will also debate hot button topics such as the advantages of blastocyst stage biopsy over Day 3 biopsy, and many more of today’s leading embryology topics!

Featured in the Webinar is Hamilton Thorne’s cutting-edge LYKOS® laser system and FDA cleared Multi-Pulse Software that provides rapid, repeated firing of the laser to facilitate removal of cells from an embryo during the trophectoderm biopsy process.

 

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CEO Message on Q4 and Year-End Earnings for 2011; Record Revenues in Q4 and Eight Consecutive Quarters of Revenue Growth

“I am pleased to report that Hamilton Thorne performed well in 2011, achieving 19% growth and record sales of over $2 million in Q4, which marks our eighth consecutive quarter of year-over-year revenue growth, and a 15.5% sales increase for the full year, despite a challenging global economy,” said David Wolf, President and Chief Executive Officer of Hamilton Thorne Ltd.

Mr. Wolf continued, “In 2012, we expect to continue to invest in both R&D and sales and marketing activities, in order to continue our steady growth trajectory while managing overhead, and moving Hamilton Thorne towards profitability and positive cash flow.”

Read the full Q4 and Year-End earnings press release by clicking here.

 

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Recording Available for Transgenics Webinar

Late to the Webinar? Missed it? Want to hear it again?

The Transgenic Technology Webinar, “Optimize Quality Assurance for Mouse Sperm Freezing and Rederivation using Computer Assisted Sperm Analysis (CASA), and Sneak Preview of Upcoming Webinar: Facilitate Fertilization through Laser-assisted IVF”  is now available to view at your convenience.

Click here to listen to the Webinar today, and stay tuned for more exciting Webinar topics in our “Transgenic Technologies” series!

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